The board layout is fairly well though out, but there are a few areas of concern. The CPU area has been crowded with the Northbridge, power regulation circuit, and ATX12V header. Heatsink airflow could be impeded if the snaking 12V power cable is not tucked away. I did have a more difficult time maneuvering the heatsink clips into place. Some of the more monstrous heatsinks may have to be removed if the 12V line needs to be unplugged. The CPU retention mechanism is a very hard plastic, and is reinforced on the underside of the board, so the board will not warp under the stress of any retention clip.