Duke has a new nemesis, and this time its not scumbag aliens! It may be even worse....

Mech Morphix has perfected GLOPP (Gluon Liquid Omega Phased Plasma), a slimy, radioactive substance that mutates living things on contact. After using his own henchman guinea pigs, turning them into grotesque beasts, he unleashed the ozze on the city of New York. With an elaborate pipeline to manufacture and ship the powerful plasma to a secret labl, Morphix plans to use it to take over the world (of course).