Windows Central published a guide showing steps to get rid of the update KB5001330 to fix profile, gaming, and BSoD problems with the Windows 10 October 2020 Update and May 2020 Update. 

Here's what you can do if Windows 10 update KB5001330 is causing issues

Did you apply the April 2021 Patch Tuesday update and your computer is now experiencing issues? You're not alone. Here's how to remove it to mitigate the problem. On April 13, Microsoft made available the update KB5001330 for computers running the Windows 10 October 2020 Update and May 2020 Update to address several issues and finally replace the legacy version of Microsoft Edge with the new Chromium version of the browser. However, it appears that the rollout is not going as smoothly as the company would have hoped.

Here's what you can do if Windows 10 update KB5001330 is causing issues