Microsoft has now pushed out a fix for these issues plus some other stability improvements



From Neowin:

With any new product launch there are sure to be some bugs. With Microsoft's new Surface Pro 4 and Surface Book entering their second week of availability, some users have been reporting several problems. The most common of these was related to an unresponsive display driver which caused sporadic screen flickering as well as some issues with external monitors.

Just days ago we reported that Microsoft was working on fixes for these various issues and today it looks like they have released a firmware update for these devices along with the corresponding change log

  Microsoft releases firmware update for Surface Book and Surface Pro 4 to fix screen flickering