3D Spotlight has posted a Flight Simulator 2000 tweak guide.

For optimal performance, you should install as many items onto the hard drive as possible. I'd recommend Ticking Install Adventures, Install interior views (Unless you use external view modes the majority all the time). Other than that install as many of the scenery files to the hard drive as possible. Particularly make sure that you install the locations around which you will be doing your flying most often, e.g. If you intend to fly in Africa mostly then it's unlikely you'll want to install the Alaska scenery.

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